A continuation of PIHKAL, TIHKAL focuses on the family of psychoactive drugs in the tryptamine family and provides a blend of biography, botanical facts, scientific speculation, and psychological and political commentary written by renowned psychopharmacologist Alexander Shulgin and his wife Ann Shulgin.

Contains over 70 experiments, complete with notes and ingredients with the focus on Tryptamines. The first half concentrates on Shulgin's spiritual journey, ideas and philosophy. Foreword by Daniel M Perrine and preface by Nicholas Saunders. Edited by Dan Joy.