Thermohydrodynamic Programming and Constructal Design in Microsystems explains the direction of a morphing system configuration that is illustrated by life evolution in nature. This is sometimes referred to as the fourth law of thermodynamics, and was first applied in thermofluidic engineering, with more recent applications in physics and biology. The book specifically focuses on synthetic modeling and constructal optimization in the design of microsystemic devices, which are of particular interest to researchers and practitioners in the sphere of micro- and nanoscale physics, a mechanistically deviation from conventional theory. The book is an important reference resource for researchers working in the area of micro- and nanosystems technology and those who want to learn more about how thermodynamics can be effectively applied at the micro level.