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This volume provides a comprehensive update on basic glutamate research, from a clinical perspective. Thus, emphasis is placed on how the different molecular players at the glutamate synapse interact to produce a postsynaptic response, how synaptic transmission is perturbed in epilepsy and other pathological conditions, and how glutamate may acquire toxic properties and lead to acute or chronic neurodegeneration. Promising targets for therapeutic strategies are discussed. A coherent picture is provided of the glutamate synapse and its molecular organization. The book therefore deals with each step in the signal process, from synthesis and vesicular uptake of glutamate to its clearance following receptor activation.

Boekdetails

Serie
Progress in Brain Research
Ondertitel
Progress in Brain Research
Formaat
Hardback
Uitgever
Elsevier Science & Technology
Imprint
Elsevier Science Ltd
Auteur
O.P. Ottersen (Dept. of Anatomy, Institute of Basic Medical Sciences, University of Oslo, POB 1105 Blindern, N-0317 Oslo, Norway) || I.A. Langmoen (Dept. of Neurosurgery, The National Hospital, Rikshospitalet, N-0027 Oslo, Norway) || L. Gjerstad (Nevrologisk avdeling, Rikshospitalet, N-0027 Oslo, Norway), Elsevier Science Ltd, Elsevier Science & Technology
ISBN-13
9780444827548
Verschijningsdatum
1998-11-09
Pagina's
462
Afmetingen
152 mm × 229 mm
Gewicht
1430 g
Land van herkomst
US

Hardback

The Glutamate Synapse as a Therapeutic Target: Volume 116

door O.P. Ottersen (Dept. of Anatomy, Institute of Basic Medical Sciences, University of Oslo, POB 1105 Blindern, N-0317 Oslo, Norway) || I.A. Langmoen (Dept. of Neurosurgery, The National Hospital, Rikshospitalet, N-0027 Oslo, Norway) || L. Gjerstad (Nevrologisk avdeling, Rikshospitalet, N-0027 Oslo, Norway)

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