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The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.

Boekdetails

Serie
Advances in Experimental Medicine and Biology
Ondertitel
Advances in Experimental Medicine and Biology
Formaat
Hardback
Uitgever
Springer International Publishing AG
Imprint
Springer International Publishing AG
Auteur
Mieczyslaw Pokorski, Springer International Publishing AG, Springer International Publishing AG
ISBN-13
9783319100111
Verschijningsdatum
2014-12-08
Editie
2015 ed.
Afmetingen
178 mm × 254 mm
Land van herkomst
NL

Hardback

Inflammatory Disorders

door Mieczyslaw Pokorski

€ 142,68
Op voorraad14 werkdagen
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