This text brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T-cell tolerance, molecular and genetic mechanisms for maintaining self-tolerance and the role of apoptosis in tolerance.

This text brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T-cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T-cell activation, and the role of apoptosis in tolerance. Consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T-cell activation during tumour therapy, anti-antigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.