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This text aims to address the need for investigators to understand the basic concepts, as well as the practical concerns, associated with the use of antisense oligonucleotides in modifying gene expression.
Applied Antisense Oligonucleotide Technology provides the basic concepts as well as the practical concerns associated with the use of antisense oligonucleotides to modify gene expression. Chapters include oligonucleotide chemistry, DNA triplex formation, delivery mechanisms, pharmocokinetics, toxicity, oligonucleotides.
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